"Life work" means that to which one will devote one's energies. It is the world of the soul, as well as the material work done in the visible world. These categories of tasks are not separate: they are not inimical to one another any more than sweeping the temple, washing the vestments, or cleaning and arranging the altar are inimical to the act of prayer. On the contrary, these tasks are prayer. They are the work of the soul in that they provide a suitable atmosphere for the cultivation of a contemplative and receptive attitude.
A saint is a person who practices the keystone human virtue of humility. Humility in the face of wealth and plenty, humility in the face of hatred and violence, humility in the face of strength, humility in the face of your own genius or lack of it, humility in the face of another's humility, humility in the face of love and beauty, humility in the face of pain and death. Saints are driven to humbling themselves before all the splendor and horror of the world because they perceive there to be something divine in it pulsing and alive beneath the hard dead surface of material things -- greater and purer than they are.