Work when there is work to do. Rest when you are tired. One thing done in peace will most likely be better than ten things done in panic.
If we just worry about the big picture, we are powerless. So my secret is to start right away doing whatever little work I can do. I try to give joy to one person in the morning, and remove the suffering of one person in the afternoon. If you and your friends do not despise the small work, a million people will remove a lot of suffering.